2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

PDF 2.47 MB

Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1834):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-132815
    Fostroxacitabine bralpamide
    Fostroxacitabine bralpamide (MIV-818) is an orally active Troxacitabine-based nucleotide proagent. Fostroxacitabine bralpamide has anticancer effects.
    Fostroxacitabine bralpamide
  • HY-138582
    N6-Methyl-dA phosphoramidite
    		99.83%
    N6-Methyl-dA phosphoramidite can be used in the synthesis of oligodeoxyribonucleotides.
    N6-Methyl-dA phosphoramidite
  • HY-125818S6
    Cytidine-5'-triphosphate-15N3 dilithium
    Cytidine-5'-triphosphate-15N3 (Cytidine triphosphate-15N3 dilithium; 5'-CTP-15N3) dilithium is 15N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.
    Cytidine-5'-triphosphate-<sup>15</sup>N<sub>3</sub> dilithium
  • HY-152752
    2’,3’-Dideoxy-3’-fluorocytidine
    2’,3’-Dideoxy-3’-fluorocytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’,3’-Dideoxy-3’-fluorocytidine
  • HY-138599
    5'-O-TBDMS-dA
    		99.89%
    5'-O-TBDMS-dA is a modified nucleoside and can be used to synthesize DNA or RNA.
    5'-O-TBDMS-dA
  • HY-108060
    Valopicitabine
    Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination.
    Valopicitabine
  • HY-130806
    Dihydrodeoxyuridine
    		98.71%
    Dihydrodeoxyuridine (H2dUrd) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Dihydrodeoxyuridine
  • HY-154054
    5′-Azido-5′-deoxyadenosine
    5′-Azido-5′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 5′-Azido-5′-deoxyadenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    5′-Azido-5′-deoxyadenosine
  • HY-101968
    2'-Deoxypseudoisocytidine
    		Chemical
    2'-Deoxypseudoisocytidine is a nucleoside analogue.
    2'-Deoxypseudoisocytidine
  • HY-138612
    5'-O-DMT-3'-O-TBDMS-Ac-rC
    		99.18%
    5'-O-DMT-3'-O-TBDMS-Ac-rC is a modified nucleoside and can be used to synthesize DNA or RNA.
    5'-O-DMT-3'-O-TBDMS-Ac-rC
  • HY-B0097R
    Floxuridine (Standard)
    		Inhibitor
    Floxuridine (Standard) is the analytical standard of Floxuridine. This product is intended for research and analytical applications. Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly(ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis. Floxuridine has antiviral effects against HSV and CMV.
    Floxuridine (Standard)
  • HY-77650
    4'-C-Azidouridine
    4'-C-azidouridine (4'-Azidouridine) is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents. 4'-C-Azidouridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    4'-C-Azidouridine
  • HY-138595
    5'-O-TBDMS-Bz-dA
    		98.37%
    5'-O-TBDMS-Bz-dA is a nucleoside with protective and modification effects.
    5'-O-TBDMS-Bz-dA
  • HY-100709
    ZPCK
    		Inhibitor ≥99.0%
    ZPCK is an oral active proagent of gemcitabine that was designed for improved oral bioavailability.
    ZPCK
  • HY-131795
    2-Methylthioadenosine
    		98.82%
    2-Methylthioadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Methylthioadenosine
  • HY-152672
    9-(β-D-Xylofuranosyl)adenine
    		99.92%
    9-(β-D-Xylofuranosyl)adenine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    9-(β-D-Xylofuranosyl)adenine
  • HY-154409
    2’-Fluoro-2’-deoxy-ara-A(Bz)-3’-phosphoramidite
    		99.88%
    2’-Fluoro-2’-deoxy-ara-A(Bz)-3’-phosphoramidite is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    2’-Fluoro-2’-deoxy-ara-A(Bz)-3’-phosphoramidite
  • HY-154513
    2’-Deoxy-5,N4-dimethylcytidine
    2’-Deoxy-5,N4-dimethylcytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Deoxy-5,N4-dimethylcytidine
  • HY-159849
    Cytidylyl-(3′,5′)-uridine
    Cytidylyl-(3′,5′)-uridine is a dinucleotide derivative that can be used to study nucleotide metabolism.
    Cytidylyl-(3′,5′)-uridine
  • HY-W008615
    5-Iodo-cytidine
    		98.21%
    5-Iodo-cytidine (5-Iodo-D-cytidine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Iodo-cytidine